Significance of serum amyloid A for the course and outcome of SARS-CoV-2 infection

Significance of serum amyloid A for the course and outcome of SARS-CoV-2 infection

Blog Article

The occurrence of a new coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), quickly became a global threat after it had spread across the continents in just a few months.Over the next three years, it caused infections in over 646.6 million people and resulted in over 6.

6 million Dab Inserts deaths.As a novel disease, Coronavirus Disease 19 (COVID-19) became the subject of intensive research.Due to various clinical manifestations of the infection with possible fatal outcomes, it became evident that a finer understanding of COVID-19 pathogenesis, clinical manifestations, and complications is necessary.

Investigation of acute-phase reaction as a component of the immune system response to infection can be very helpful.Serum amyloid A (SAA) was investigated for this purpose as one of the acute-phase reactants primarily synthesized by the hepatocytes in response to pro-inflammatory cytokines.It has been found that elevated SAA levels were independent factors for gastrointestinal manifestations and liver injury during COVID-19 but also one of the factors in theplayfulcollectivees.shop COVID19-associated coagulopathy.

Studies showed that SAA levels positively correlate with disease severity and prognosis.Patients with severe infection demonstrated significantly higher levels of SAA.Higher SAA levels were observed in COVID-19 patients with chronic diseases such as diabetes mellitus, hypertension, cerebrovascular diseases, and obesity, all recognized as independent risk factors for critical disease and poor prognosis.

Patients with COVID-19 who died had higher levels of SAA than survivors.This short review will summarize current studies and knowledge about SSA in COVID-19, its role in the pathogenesis of SARS-CoV-2 infection, and its clinical usefulness in COVID-19 patients.